Characterization of cancer-associated missense mutations in MDM2.


MDM2 is an E3 ubiquitin ligase that binds the N-terminus of p53 and promotes its ubiquitin-dependent degradation. Elevated levels of MDM2 due to overexpression or gene amplification can contribute to tumor development by suppressing p53 activity. Since MDM2 is an oncogene, we explored the possibility that other genetic lesions, namely missense mutations… (More)
DOI: 10.1080/23723556.2015.1125986


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@article{Chauhan2016CharacterizationOC, title={Characterization of cancer-associated missense mutations in MDM2.}, author={Krishna M. Chauhan and Gopalakrishnan Ramakrishnan and Madhusudhan Kollareddy and Luis Alfonso Martinez}, journal={Molecular & cellular oncology}, year={2016}, volume={3 2}, pages={e1125986} }