Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3.

@article{Block1998CharacterizationOC,
  title={Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3.},
  author={Karen L. Block and H P Vornlocher and John W. B. Hershey},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 48},
  pages={31901-8}
}
Eukaryotic translation initiation factor 3 (eIF3) is a large multisubunit complex that plays a central role in the initiation of translation. It binds to 40 S ribosomal subunits resulting in dissociation of 80 S ribosomes, stabilizes initiator methionyl-tRNA binding to 40 S subunits, and is required for mRNA binding. eIF3 has an aggregate molecular mass of approximately 600 kDa and comprises at least 10 subunits. The cDNAs encoding eight of the subunits have been cloned previously (p170, p116… CONTINUE READING
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