Characterization of cDNA for precursor of human luteinizing hormone releasing hormone

@article{Seeburg1984CharacterizationOC,
  title={Characterization of cDNA for precursor of human luteinizing hormone releasing hormone},
  author={P. H. Seeburg and John P. Adelman},
  journal={Nature},
  year={1984},
  volume={311},
  pages={666-668}
}
Human reproduction is controlled by the hypothalamic–pituitary–gonadal axis laid down early in fetal development. Luteinizing hormone releasing hormone (LHRH), also termed gonadotropin releasing hormone (GnRH), is a decapeptide1,2 and is a key molecule in this control circuit. It is produced by hypothalamic neurones, secreted in a pulsatile manner into the capillary plexus of the median eminence and effects the release of luteinizing hormone and follicle stimulating hormone from gonadotropic… 
Evolutionary aspects of gonadotropin-releasing hormone and its receptor
TLDR
Evidence suggests that in most species the early-evolved and highly conserved chicken GnRH II has a neurotransmitter function, while the second form, which varies across classes, has a physiologic role in regulating gonadotropin release.
Gonadotropin-Releasing Hormone: Differentiation of Structure and Function During Evolution
TLDR
It is now clear that GnRH is a member of a family of homologous peptides, has multiple functions, is located both within and out of the central nervous system and has well-studied neuro-transmitter actions.
Origin of mammalian gonadotropin-releasing hormones.
TLDR
Studying of GnRH peptides and their genes have altered views on the origin, function, and regulation of this neuropeptide, and novel functions, in addition to the release of gonadotropins exist.
Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells
TLDR
The recent availability of immortalized neuronal cell lines that produce GnRH allows investigators for the first time to begin to dissect the factors that directly regulate GnRH gene expression.
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