Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase.

@article{Acheampong1996CharacterizationOB,
  title={Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase.},
  author={Andrew A Acheampong and Dao-Ngoc Chien and S Lam and Sylvia V Vekich and Alan P. Breau and J. I. Usansky and Diana Harcourt and S A Munk and H Nguyen and Michael E Garst and Diane D-S. Tang-Liu},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1996},
  volume={26 10},
  pages={1035-55}
}
1. In vitro metabolism of 14C-brimonidine by the rat, rabbit, dog, monkey and human liver fractions was studied to assess any species differences. In vitro metabolism with rabbit liver aldehyde oxidase and human liver slices, and in vivo metabolism in rats were also investigated. The hepatic and urinary metabolites were characterized by liquid chromatography and mass spectrometry. 2. Up to seven, six, 11 and 14 metabolites were detected in rat liver S9 fraction, human liver S9 fraction, human… CONTINUE READING