Characterization of brainstem peptide YY (PYY) neurons.

  title={Characterization of brainstem peptide YY (PYY) neurons.},
  author={Maria M. Glavas and Bernadette E Grayson and Summer E Allen and Daniel R Copp and M Susan Smith and Michael Alexander Cowley and Kevin L. Grove},
  journal={The Journal of comparative neurology},
  volume={506 2},
Peptide YY (PYY), a member of the NPY superfamily of peptides, is predominantly synthesized by the colon and is thought to act on both the gut and brain to modulate energy homeostasis. Although neurons expressing PYY mRNA have also been reported in the brainstem, little is known about their physiological role and study of their projections has been problematic due to crossreactivity of PYY antibodies with NPY. In the present study we examined the localization of central PYY cell bodies in the… CONTINUE READING