Characterization of brain blood flow and the amplitude of low-frequency fluctuations in major depressive disorder: A multimodal meta-analysis.

@article{Li2017CharacterizationOB,
  title={Characterization of brain blood flow and the amplitude of low-frequency fluctuations in major depressive disorder: A multimodal meta-analysis.},
  author={Wen-Bin Li and Ziqi Chen and Ming Wu and Hongyan Zhu and Lei Gu and Youjin Zhao and Weihong Kuang and Feng ‐ Rong Bi and Graham J. Kemp and Qiyong Gong},
  journal={Journal of affective disorders},
  year={2017},
  volume={210},
  pages={303-311}
}
BACKGROUND In healthy subjects, there is an association between amplitude of low-frequency fluctuations (ALFF) and regional cerebral blood flow (rCBF). To date, no published meta-analysis has investigated changes in the regional ALFF in medication-free depressed patients. METHODS In this study, we aimed to explore whether resting-state rCBF and ALFF changes co-occur in the depressed brain without the potential confound of medication. Using signed differential mapping (SDM), we conducted two… CONTINUE READING