Characterization of big bang, a novel gene encoding for PDZ domain-containing proteins that are dynamically expressed throughout Drosophila development.

@article{Kim2006CharacterizationOB,
  title={Characterization of big bang, a novel gene encoding for PDZ domain-containing proteins that are dynamically expressed throughout Drosophila development.},
  author={Sabrina Y Kim and Maia K Renihan and Gabrielle L Boulianne},
  journal={Gene expression patterns : GEP},
  year={2006},
  volume={6 5},
  pages={504-18}
}
PDZ (PSD-95, Discs-large, ZO-1) domain proteins often function as scaffolding proteins and have been shown to play important roles in diverse cellular processes such as the establishment and maintenance of cell polarity, and signal transduction. Here, we report the identification and cloning of a novel Drosophila melanogaster gene that is predicted to produce several different PDZ domain-containing proteins through alternative promoter usage and alternative splicing. This gene, that we have… CONTINUE READING