Characterization of benzoquinone-peptide adducts by electrospray mass spectrometry.

  title={Characterization of benzoquinone-peptide adducts by electrospray mass spectrometry.},
  author={Daniel E Mason and Daniel C. Liebler},
  journal={Chemical research in toxicology},
  volume={13 10},
Benzoquinone adducts were prepared with model peptides to identify characteristic features of adduct fragmentation in tandem mass spectrometry (MS) experiments. Model peptides contained cysteine and had a molecular mass of less than 2 kDa to facilitate peptide fragmentation in tandem MS analyses. Peptides were adducted with an excess of benzoquinone, and the adducts were analyzed by LC/MS. Adducts were identified by addition of 108 Da to the monoisotopic mass of the peptide, except in the case… CONTINUE READING


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