Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis.

@article{Fritsch2002CharacterizationOA,
  title={Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis.},
  author={Ruth Fritsch and Daniela Eselb{\"o}ck and Karl Skriner and Beatrice Jahn-Schmid and Clemens Scheinecker and Barbara Bohle and Makiyeh Tohidast-Akrad and Silvia Hayer and Josef Neum{\"u}ller and Seraf{\'i}n Pi{\~n}ol-Roma and Josef S Smolen and Guenter Steiner},
  journal={Journal of immunology},
  year={2002},
  volume={169 2},
  pages={1068-76}
}
The role of autoimmune reactions in the pathogenesis of rheumatoid arthritis (RA) is poorly understood. To address this issue we have investigated the spontaneous T cell response to two well-characterized humoral autoantigens in RA patients and controls: 1) the heterogeneous nuclear ribonucleoprotein A2, i.e., the RA33 Ag (A2/RA33), and 2) filaggrin in unmodified and citrullinated forms. In stimulation assays A2/RA33 induced proliferative responses in PBMC of almost 60% of the RA patients but… CONTINUE READING

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