Characterization of attenuated strains of Rift Valley fever virus.

  title={Characterization of attenuated strains of Rift Valley fever virus.},
  author={Cindy A Rossi and Michael J. Turell},
  journal={The Journal of general virology},
  volume={69 ( Pt 4)},
The wild-type ZH501 strain of Rift Valley fever (RVF) virus and two small-plaque strains (T1 and T46) derived from it were characterized by plaque size, pathogenicity for hamsters and ability to replicate in Vero cells. Additionally, a mutagenized, attenuated, large-plaque, vaccine-candidate strain of RVF virus (ZH548-M12) was also studied. Infections with either the ZH501 or T46 strain were uniformly fatal to hamsters. In contrast, nearly all hamsters infected with either the T1 or ZH548-M12… CONTINUE READING