Characterization of astrocyte-specific conditional knockouts.

@article{Casper2007CharacterizationOA,
  title={Characterization of astrocyte-specific conditional knockouts.},
  author={Kristen B. Casper and K Wynne - Jones and Ken D. McCarthy},
  journal={Genesis},
  year={2007},
  volume={45 5},
  pages={292-9}
}
Conditional gene knockouts are a very powerful tool for elucidating gene function in animal physiology and behavior. To obtain cell-specific knockouts, a promoter is utilized that drives expression of Cre recombinase specifically to the cell population of interest. We describe several transgenic lines of mice that were created in an attempt to obtain astrocyte-specific gene recombination. A 2 kb fragment from the human glial fibrillary acidic protein promoter is utilized to drive expression of… CONTINUE READING

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