Characterization of antigen receptor response elements within the interleukin-2 enhancer.

@article{Durand1988CharacterizationOA,
  title={Characterization of antigen receptor response elements within the interleukin-2 enhancer.},
  author={D Durand and Jason Philip Shaw and M. R. Bush and Robert Edward Replogle and Rama M. Belagaje and Gerald R Crabtree},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 4},
  pages={1715-24}
}
T-cell activation and induction of interleukin-2 (IL-2) expression in human T lymphocytes require both interaction of foreign antigen with the T-cell antigen receptor and protein kinase C (PKC) stimulation. Agents such as phorbol 12-myristate 13-acetate (PMA) that stimulate PKC augment the effects of antigen but are not sufficient for IL-2 activation. By analysis of deletion mutants, we identified three DNA sequences extending from -73 to -89, -217 to -255, and -263 to -279, designated IL-2… CONTINUE READING

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