Characterization of antidepressant-like effects of p-synephrine stereoisomers

@article{Kim2001CharacterizationOA,
  title={Characterization of antidepressant-like effects of p-synephrine stereoisomers},
  author={Keen Kim and Hee-doo Kim and Jun-Sub Jung and Ran-Sook Woo and Hee-sung Kim and Hong-Won Suh and Yung-Hi Kim and Dong-Keun Song},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2001},
  volume={364},
  pages={21-26}
}
Abstract. We previously reported that p-synephrine has antidepressant-like activity in the murine models of forced swimming and tail suspension. In the present study, we characterized antidepressant-like effects of p-synephrine stereoisomers in both in vivo and in vitro systems. In the tail suspension test, S-(+)-p-synephrine (3 mg/kg, p.o.) reduced the duration of immobility, while R-(-)-p-synephrine (0.3–3 mg/kg, p.o.) had no effect. S-(+)-p-synephrine (0.3, 1 and 3 mg/kg, p.o.) and R-(-)-p… Expand
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