Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies

@inproceedings{Qiu2010CharacterizationOA,
  title={Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies},
  author={Xiaoxing Qiu and Priscilla A Swanson and Ka-Cheung Luk and Bailin Tu and Francois Villinger and Jaydip Das Gupta and Robert H. Silverman and Eric A Klein and Sushil G. Devare and G. Schochetman and John Hackett},
  booktitle={Retrovirology},
  year={2010}
}
Xenotropic Murine Leukemia Virus-related Virus (XMRV) is a human gammaretrovirus recently identified in prostate cancer tissue and in lymphocytes of patients with chronic fatigue syndrome. To establish the etiologic role of XMRV infection in human disease requires large scale epidemiologic studies. Development of assays to detect XMRV-specific antibodies would greatly facilitate such studies. However, the nature and kinetics of the antibody response to XMRV infection have yet to be determined… CONTINUE READING

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Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses.

Proceedings of the National Academy of Sciences of the United States of America • 2010
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