Characterization of anti-DNA B cells that escape negative selection.

  title={Characterization of anti-DNA B cells that escape negative selection.},
  author={Margaret S. Bynoe and Linda A. Spatz and Betty Diamond},
  journal={European journal of immunology},
  volume={29 4},
One of the challenges in the study of autoimmunity is to understand which autoreactive cells are subject to regulation and what mechanisms of regulation are operative. In mice transgenic for the R4A-gamma2b heavy chain of an anti-double stranded (ds) DNA antibody, the gamma2b heavy chain can pair with the full spectrum of endogenous light chains to produce a multitude of antibodies, including anti-dsDNA antibodies of different affinities and fine specificities. We have previously demonstrated… CONTINUE READING

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