Characterization of androgen receptor structure and nucleocytoplasmic shuttling of the rice field eel.

@article{Zhou2010CharacterizationOA,
  title={Characterization of androgen receptor structure and nucleocytoplasmic shuttling of the rice field eel.},
  author={Fang Zhou and Wei Zhao and Zhixiang Zuo and Yue Sheng and Xiang Zhou and Yu Hou and Hanhua Cheng and Rongjia Zhou},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 47},
  pages={37030-40}
}
Androgen receptor (AR) plays a critical role in prostate cancer and male sexual differentiation. We have identified AR from a primitive vertebrate with a sex reversal characteristic, the rice field eel. AR of this species (eAR) is distinct from human AR, especially in the ligand binding domain (LBD), and its expression in gonads shows an increasing tendency during gonadal transformation from ovary via ovotestis to testis. eAR has a restricted androgen-dependent transactivation function after a… CONTINUE READING