Characterization of an unusual folding pattern in a catalytically active guanine quadruplex structure.

@article{Majhi2006CharacterizationOA,
  title={Characterization of an unusual folding pattern in a catalytically active guanine quadruplex structure.},
  author={P. R. Majhi and Richard Shafer},
  journal={Biopolymers},
  year={2006},
  volume={82 6},
  pages={558-69}
}
In the presence of certain metal ions, DNA and RNA can form guanine quadruplex structures, which have been proposed to play a functional role in a variety of biological processes. An 18-nucleotide DNA oligomer, PS2.M, d(GTG3TAG3CG3T2G2), was previously reported to bind hemin and the resulting complex exhibited peroxidase activity. It was proposed that PS2.M folds unimolecularly into an antiparallel quadruplex with unusual, single-base loops and terminal guanines positioned in adjacent quartets… CONTINUE READING