Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta.

  title={Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta.},
  author={Marie V. St-Pierre and Bruno Hagenbuch and Bernhard Ugele and Peter Meier and Thomas Stallmach},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={87 4},
Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates. We investigated whether members of the OATP gene family could mediate fetal-maternal transfer of anionic steroid conjugates in the human placenta. OATP-B (gene symbol SLC21A9) was isolated from a placenta cDNA library. An antiserum to OATP-B detected an 85-kDa protein in basal… CONTINUE READING


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