Characterization of an ocular photopigment capable of driving pupillary constriction in mice

@article{Lucas2001CharacterizationOA,
  title={Characterization of an ocular photopigment capable of driving pupillary constriction in mice},
  author={Robert J. Lucas and Ronald H. Douglas and Russell G. Foster},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={621-626}
}
This work demonstrates that transgenic mice lacking both rod and cone photoreceptors (rd/rd cl) retain a pupillary light reflex (PLR) that does not rely on local iris photoreceptors. These data, combined with previous reports that rodless and coneless mice show circadian and pineal responses to light, suggest that multiple non-image-forming light responses use non-rod, non-cone ocular photoreceptors in mice. An action spectrum for the PLR in rd/rd cl mice demonstrates that over the range 420… Expand
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  • 2004
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