Characterization of an influenza A H5N2 reassortant as a candidate for live-attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential.

@article{Desheva2006CharacterizationOA,
  title={Characterization of an influenza A H5N2 reassortant as a candidate for live-attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential.},
  author={Julia A Desheva and Xui Hua Lu and Andrey Rekstin and Larisa Rudenko and David Swayne and Nancy J. Cox and Jacqueline M. Katz and Alexander I. Klimov},
  journal={Vaccine},
  year={2006},
  volume={24 47-48},
  pages={6859-66}
}
We generated a high-growth 7:1 reassortant (Len17/H5) that contained the hemagglutinin (HA) gene from non-pathogenic A/Duck/Potsdam/1402-6/86 (H5N2) virus and other genes from the cold-adapted (ca) attenuated A/Leningrad/134/17/57 (H2H2) strain. Len17/H5 demonstrated an attenuated phenotype in mice and did not infect chickens. Mice administered Len17/H5 either as a live-attenuated intranasal vaccine or as an inactivated intramuscular vaccine were substantially protected from lethal challenge… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Antigenic characteristics of recent avian influenza A H 5 N 1 viruses isolated from humans

  • LE Edwards, DC Nguyen, XH Lu
  • Nature
  • 2004

Reassortment between avian apathogenic and human attenuated cold - adapted viruses as an approach for preparing influenza pandemic vaccines

  • YZ Ghendon, FI Polezhaev, KV Lisovskaya
  • 2004

Similar Papers

Loading similar papers…