Characterization of an improved double hemorrhage rat model for the study of delayed cerebral vasospasm.

@article{Lee2008CharacterizationOA,
  title={Characterization of an improved double hemorrhage rat model for the study of delayed cerebral vasospasm.},
  author={Jin-Yul Lee and Dah-Luen Huang and Richard F. Keep and Oren Sagher},
  journal={Journal of neuroscience methods},
  year={2008},
  volume={168 2},
  pages={358-66}
}
Rats have been shown in several studies to develop delayed cerebral vasospasm after subarachnoid hemorrhage (SAH). However, the rat model has not yet been fully validated, and there are number of methodological issues. In this study, we present an improved double hemorrhage rat model for studies of delayed cerebral vasospasm. Double hemorrhage was induced at an interval of 24h using a PE-10 catheter introduced into the cisterna magna through a parieto-occipital burr hole. Blood volumes… CONTINUE READING

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