Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure.

@article{Dibb2009CharacterizationOA,
  title={Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure.},
  author={Katharine M Dibb and Jessica D Clarke and Margaux A. Horn and Mark A. Richards and Helen K. Graham and David J. Eisner and Andrew W. Trafford},
  journal={Circulation. Heart failure},
  year={2009},
  volume={2 5},
  pages={482-9}
}
BACKGROUND In ventricular myocytes, the majority of structures that couple excitation to the systolic rise of Ca(2+) are located at the transverse tubular (t-tubule) membrane. In the failing ventricle, disorganization of t-tubules disrupts excitation contraction coupling. The t-tubule membrane is virtually absent in the atria of small mammals resulting in spatiotemporally distinct profiles of intracellular Ca(2+) release on stimulation in atrial and ventricular cells. The aims of this study… CONTINUE READING