Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF

@article{Chen1985CharacterizationOA,
  title={Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF},
  author={Pojen P. Chen and Shemian Fong and Richard A. Houghten and Dennis Anthony Carson},
  journal={The Journal of Experimental Medicine},
  year={1985},
  volume={161},
  pages={323 - 331}
}
Recently, an antiidiotype to human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors) was found to react also with human IgG. This peculiar antiidiotype was called an 'epibody'. We describe the induction of a similar epibody by immunization with a synthetic peptide (corresponding to one hypervariable region of the IgM-RF Glo). The results confirm the existence of epibodies, and provide the possible molecular basis of the epibody phenomenon. 

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