Characterization of an early afterhyperpolarization after a brief train of action potentials in rat hippocampal neurons in vitro.

@article{Williamson1990CharacterizationOA,
  title={Characterization of an early afterhyperpolarization after a brief train of action potentials in rat hippocampal neurons in vitro.},
  author={Anne Williamson and Bradley E. Alger},
  journal={Journal of neurophysiology},
  year={1990},
  volume={63 1},
  pages={72-81}
}
1. In rat hippocampal pyramidal cells in vitro, a brief train of action potentials elicited by direct depolarizing current pulses injected through an intracellular recording electrode is followed by a medium-duration afterhyperpolarization (mAHP) and a longer, slow AHP. We studied the mAHP with the use of current-clamp techniques in the presence of dibutyryl cyclic adenosine 3',5'-monophosphate (cAMP) to block the slow AHP and isolate the mAHP. 2. The mAHP evoked at hyperpolarized membrane… CONTINUE READING