Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online.

@article{Walker1998CharacterizationOA,
  title={Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online.},
  author={Amy H. Walker and J. Michael Jaffe and Suba Gunasegaram and Shelly A Cummings and C. S. Huang and H. D. Chern and Olufunmilayo I. Olopade and Barbara L. Weber and Timothy R. Rebbeck},
  journal={Human mutation},
  year={1998},
  volume={12 4},
  pages={289}
}
CYP3A4 is involved in the metabolism of numerous biologically active compounds, including testosterone. A genetic variant located in the P450NF (nifedipine) specific element (NFSE) has been identified that disrupts a transciptional regulatory element located in the 5' regulatory region of CYP3A4. The CYP3A4 variant (CYP3A4-V) is associated with the clinical presentation of prostate cancer. There are significant differences in CYP3A4 metabolism and rates of prostate cancer across ethnic groups… CONTINUE READING

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