Characterization of an RNA granule from developing brain.

  title={Characterization of an RNA granule from developing brain.},
  author={George Elvira and Sylwia Wasiak and Vanessa E Blandford and Xin-Kang Tong and Alexandre Serrano and Xiaotang Fan and Mar{\'i}a del Rayo S{\'a}nchez-Carbente and Florence Servant and Alexander W. Bell and Daniel Boismenu and Jean-Claude Lacaille and Peter S McPherson and Luc Desgroseillers and Wayne S. Sossin},
  journal={Molecular & cellular proteomics : MCP},
  volume={5 4},
In brain, mRNAs are transported from the cell body to the processes, allowing for local protein translation at sites distant from the nucleus. Using subcellular fractionation, we isolated a fraction from rat embryonic day 18 brains enriched for structures that resemble amorphous collections of ribosomes. This fraction was enriched for the mRNA encoding beta-actin, an mRNA that is transported in dendrites and axons of developing neurons. Abundant protein components of this fraction, determined… CONTINUE READING
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