Characterization of an HL-60 cell variant resistant to the antineoplastic ether lipid 1-O-octadecyl-2-o-methyl-rac-glycero-3-phosphocholine

@article{Small1997CharacterizationOA,
  title={Characterization of an HL-60 cell variant resistant to the antineoplastic ether lipid 1-O-octadecyl-2-o-methyl-rac-glycero-3-phosphocholine},
  author={George W Small and Jay C. Strum and Larry W. Daniel},
  journal={Lipids},
  year={1997},
  volume={32},
  pages={715-723}
}
A resistant cell line (HL-60R) was selected by incubating HL-60 cells with increasing concentrations of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) and used to examine the mechanism of resistance to the antineoplastic ether-linked lipid. The HL-60R cells exhibited a>10-fold increase in resistance when measured by [3H]-thymidine incorporation in comparison to the HL-60 cell line. ET-18-OCH3 binding occurred at 4°C and was not saturable at the concentrations tested (1–100… CONTINUE READING

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