Characterization of an F-actin-binding domain in the cytoskeletal protein vinculin

  title={Characterization of an F-actin-binding domain in the cytoskeletal protein vinculin},
  author={Annette R Menkel and Martina Kroemker and P Bubeck and Melanie Ronsiek and G. Nikolai and Brigitte M. Jockusch},
  journal={The Journal of Cell Biology},
  pages={1231 - 1240}
Vinculin, a major structural component of vertebrate cell-cell and cell-matrix adherens junctions, has been found to interact with several other junctional components. In this report, we have identified and characterized a binding site for filamentous actin. These results included studies with gizzard vinculin, its proteolytic head and tail fragments, and recombinant proteins containing various gizzard vinculin sequences fused to the maltose binding protein (MBP) of Escherichia coli. In… CONTINUE READING
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pression of vinculin expression by antisense transfection confers changes in cell morphology , motility , and anchorage - dependent growth of 3 T 3 cells

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Suppression of tumorgenicity in transformed cells after transfection with vinculin eDNA

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