Characterization of an Enzyme reducing Pyrroline-5-Carboxylate to Proline

  title={Characterization of an Enzyme reducing Pyrroline-5-Carboxylate to Proline},
  author={Marion E. Smith and David M. Greenberg},
SEVERAL lines of evidence serve to establish glutamic-γ-semialdehyde as the key intermediate in the pathway of the biosynthesis of proline from either glutamic acid or ornithine1,2. Since glutamic-γ-semialdehyde spontaneously cyclizes nearly completely to Δ1-pyrroline-5-carboxylic acid2, hydrogenation of the latter becomes a key reaction in the biogenesis of proline. 
Purification to homogeneity of pyrroline-5-carboxylate reductase of barley.
From the pH profiles, the specific activities and thermodynamic considerations, it is concluded that the plant proline dehydrogenase functions in vivo as a pyrroline-5-carboxylate reductase.
Diversity, properties and functions of bacterial arginases.
The regulation and specific functions of the arginase pathway are described as well as key characteristics of related arginine catabolic pathways are summarized.
Biocatalytic Imine Reduction and Reductive Amination of Ketones
Chiral amines represent a prominent functional group in pharmaceuticals and agrochemicals and are hence attractive targets for asymmetric synthesis. Since the pharmaceutical industry has identified
Der cytochemische Nachweis von Prolin-Dehydrogenasen, Acetaldehyd-Dehydrogenasen und Dihydroliponsäure-Dehydrogenase in den Zellen vonSaccharomyces cerevisiae
SummaryUsing the tetrazolium salt Nitro-BT, the following dehydrogenases can be demonstrated cytochemically in the cells ofSaccharomyces cerevisiae: (1)Proline dehydrogenase activity: it cannot be
Metabolism of proline and the hydroxyprolines.
Proline Biosynthesis: The Glutamate Pathway and Proline Degradation: The Om Pathway.