Characterization of alternatively spliced isoforms of the type I interleukin-1 receptor on iNOS induction in rat hepatocytes.

@article{Yamada2007CharacterizationOA,
  title={Characterization of alternatively spliced isoforms of the type I interleukin-1 receptor on iNOS induction in rat hepatocytes.},
  author={Masanori Yamada and Mikio Nishizawa and Richi Nakatake and Kozo Habara and Hideyuki Yoshida and Takashi Ozaki and Kosuke Matsui and Yoshinori Hamada and Yasuo Kamiyama and Seiji Ito and Tadayoshi Okumura},
  journal={Nitric oxide : biology and chemistry},
  year={2007},
  volume={17 2},
  pages={98-105}
}
In animal models of liver injury, proinflammatory cytokines are implicated in inducing iNOS, which is followed by the production of NO in hepatocytes. Previously we have reported that the up-regulation of type I IL-1 receptor (IL-1RI) is required for the transcriptional activation of iNOS gene, in concert with the activation of transcription factor NF-kappaB. In this study, we found three alternatively spliced isoforms of IL-1RI in primary cultured rat hepatocytes: two (long and short) membrane… CONTINUE READING

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