Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells.

@article{Yu1994CharacterizationOA,
  title={Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells.},
  author={Jiyeon Yu and Shanmugam Nagarajan and Etsuko Ueda and Jozo Knez and Robert Bob Petersen and M. Edward Medof},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={1994},
  volume={27 2},
  pages={195-201}
}
The genetic lesion in paroxysmal nocturnal hemoglobinuria (PNH) cells resides in a DNA element that 1) encodes a product required for assembly of GlcNAc-inositol phospholipid and 2) is commonly affected in different patients. In this study, three alternative mRNA transcripts (1600, 1200, and 950 bp) that derive from this genetic element in normal cells were… CONTINUE READING