Characterization of alkali induced formation of lanthionine, trisulfides, and tetrasulfides from peptide disulfides using negative ion mass spectrometry

@article{Thakur2009CharacterizationOA,
  title={Characterization of alkali induced formation of lanthionine, trisulfides, and tetrasulfides from peptide disulfides using negative ion mass spectrometry},
  author={Suman Siddharth Thakur and Padmanabhan Balaram},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2009},
  volume={20},
  pages={783-791}
}
Peptide disulfides are unstable under alkaline conditions, resulting in the formation of products containing lanthionine and polysulfide linkages. Electrospray ionization mass spectrometry has been used to characterize major species obtained when cyclic and acyclic peptide disulfides are exposed to alkaline media. Studies on a model cyclic peptide disulfide () and an acyclic peptide, oxidized glutathione, bis (γGlu - Cys - Gly - COOH), are described. Disulfide cleavage reactions are initiated… CONTINUE READING

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