Characterization of aldosterone-induced potassium secretion in rat distal colon.

@article{Sweiry1989CharacterizationOA,
  title={Characterization of aldosterone-induced potassium secretion in rat distal colon.},
  author={J H Sweiry and Henry Joseph Binder},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={83 3},
  pages={844-51}
}
The role of apical and basolateral membranes in aldosterone-induced active potassium (K) secretion in rat distal colon was investigated by measuring mucosal-to-serosal (Jms) and serosal-to-mucosal (Jsm) 42K fluxes (mueq.h-1.cm-2) across isolated stripped mucosa under short-circuit conditions in normal and secondary-hyperaldosterone animals. In normal colons mucosal tetraethylammonium (TEA; 30 mM) or barium (Ba; 5 mM), but not cesium (Cs; 15 mM), reduced Jsm without affecting Jms. In aldosterone… CONTINUE READING
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