Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries.

  title={Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries.},
  author={Karen B Jourdan and Nicola A Mason and L. -K. Long and P G Philips and Martin R Wilkins and Nicholas W Morrell},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={280 6},
Activation of adenylyl cyclase (AC), of which there are 10 diversely regulated isoforms, is important in regulating pulmonary vascular tone and remodeling. Immunohistochemistry in rat lungs demonstrated that AC2, AC3, and AC5/6 predominated in vascular and bronchial smooth muscle. Isoforms 1, 4, 7, and 8 localized to the bronchial epithelium. Exposure of animals to hypoxia did not change the pattern of isoform expression. RT-PCR confirmed mRNA expression of AC2, AC3, AC5, and AC6 and… CONTINUE READING


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Multiple subtypes of adenylyl cyclases are expressed in human airway smooth muscle cells (Abstract)

  • CW Emala, D Xu, IP. Hall
  • Am J Respir Crit Care Med 161:
  • 2000
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