Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC.

@article{Hewlett1993CharacterizationOA,
  title={Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC.},
  author={Erik L. Hewlett and Mary C. Gray and Ingrid E Ehrmann and N J Maloney and Angela de Souza Otero and Lillian Gray and Margaretta M Allietta and G{\'a}bor Szab{\'o} and Alison A Weiss and Eileen M. Barry},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 11},
  pages={7842-8}
}
Bordetella pertussis adenylate cyclase (AC) toxin has the abilities to 1) enter target cells where it catalyzes cyclic AMP production and 2) lyse sheep erythrocytes, and these abilities require post-translational modification by the product of an accessory gene cyaC (Barry, E. M., Weiss, A. A., Ehrmann, E. E., Gray, M. C., Hewlett, E. L., and Goodwin, M. St. M. (1991) J. Bacteriol. 173, 720-726). In the present study, AC toxin has been purified from an organism with a mutation in cyaC, BPDE386… CONTINUE READING