Characterization of adenosine receptors in brush-border membranes from pig kidney.

  title={Characterization of adenosine receptors in brush-border membranes from pig kidney.},
  author={J. Blanco and Enric I. Canela and Josefa Mallol and Carmen Lluis and Rafael Franco},
  journal={British journal of pharmacology},
  volume={107 3},
1. The adenosine receptors from pig kidney proximal tubules have been studied in membrane vesicle preparations derived from either luminal (brush-border membranes-BBM-) or basolateral (BL) sides. There was a substantial amount of A2-like NECA binding in both preparations, but the A1 subtype of adenosine receptors was not found in either BBM or BL membranes. The use of [3H]-CGS21680 which is a more specific ligand for A2a receptors revealed true adenosine receptors in the BBM. 2. The kinetic… CONTINUE READING


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