Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study

@article{Ma2001CharacterizationOA,
  title={Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study},
  author={Sk Ma and Tom Y.-H. Wan and Atc Cheuk and Lf Fung and G. D. Chan and Shin Yee Chan and Sam Yoel Ha and Linda Chan},
  journal={Leukemia},
  year={2001},
  volume={15},
  pages={1442-1447}
}
TEL/AML1 gene fusion that results from a cryptic t(12;21) is the most common genetic aberration in childhood B-lineage acute lymphoblastic leukemia (ALL). While the translocation may initiate the leukemic process, critical secondary genetic events are currently believed to be pivotal for leukemogenesis. We investigated 12 cases of childhood ALL with TEL/AML1 gene fusion by fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) and documented additional or… CONTINUE READING

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