Characterization of acute 4,4'-methylene dianiline hepatotoxicity in the rat.

Abstract

Methylene dianiline (DDM) is a chemical intermediate in the production of isocyanates and other industrial chemicals, and it is hepatotoxic in humans. The acute hepatotoxicity of orally administered DDM was characterized in rats. Rats receiving DDM (25-225 mg/kg, per os) demonstrated a dose-dependent elevation in serum alanine aminotransferase activity, g… (More)

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@article{Bailie1993CharacterizationOA, title={Characterization of acute 4,4'-methylene dianiline hepatotoxicity in the rat.}, author={Marc B Bailie and Thomas P. Mullaney and Roswith Roth}, journal={Environmental Health Perspectives}, year={1993}, volume={101}, pages={130 - 133} }