Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.

@article{Goddard1991CharacterizationOA,
  title={Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.},
  author={Alan D. Goddard and Julian Borrow and Paul S. Freemont and E. Solomon},
  journal={Science},
  year={1991},
  volume={254 5036},
  pages={1371-4}
}
The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha (RARA) gene to the PML gene. Characterization of PML revealed that it is a putative zinc finger protein and potential transcription factor that is commonly expressed, with at least three major transcription products. PML breakpoints cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells with translocations characteristically… CONTINUE READING

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