Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase.

@article{Shimada1999CharacterizationOA,
  title={Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase.},
  author={Toshifumi Shimada and Hiroyuki Nakamura and E Ohuchi and Yutaka Fujii and Yasuko Murakami and Hiroshi Sato and Motoharu Seiki and Yasunori Okada},
  journal={European journal of biochemistry},
  year={1999},
  volume={262 3},
  pages={907-14}
}
Membrane type 3 matrix metalloproteinase (MT3-MMP), an activator for the zymogen of MMP-2 (proMMP-2, or progelatinase A), is known to be expressed in human placenta, brain, lung and rat vascular smooth muscle cells, but information about its biochemical properties is limited. In the present study, we expressed and purified a truncated form of MT3-MMP lacking the transmembrane and intracytoplasmic domain (DeltaMT3) and characterized the enzyme biochemically. DeltaMT3 digested type III collagen… CONTINUE READING

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