Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.

  title={Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.},
  author={Akira Nakai and Susumu Seino and Akihiro Sakurai and Illya Szilak and Graeme I. Bell and Leslie J Degroot},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 8},
A cDNA encoding a specific form of thyroid hormone receptor expressed in human liver, kidney, placenta, and brain was isolated from a human kidney library. Identical clones were found in human placenta and HepG2 cDNA libraries. The cDNA encodes a 490-amino acid protein (Mr, 54,824). When expressed and translated in vitro, the protein product binds triiodothyronine with Ka of 2.3 X 10(9) M-1. This protein, designated human thyroid hormone receptor type alpha 2 (hTR alpha 2), has the same domain… CONTINUE READING
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