Characterization of a swine chromosome-specific centromeric higher-order repeat

  title={Characterization of a swine chromosome-specific centromeric higher-order repeat},
  author={M. A. Janzen and L. B. Buoen and Fangming Zhao and Charles Francis Louis},
  journal={Mammalian Genome},
The centromeric region of swine chromosomes is comprised of tandemly repeated, divergent DNA monomer units. Here we report that these divergent DNA monomer sequences are organized into higher-order repeats, analogous to the hierarchical organization of α-satellite monomers in human centromeres. In this study, a centromeric cosmid clone was shown to be comprised entirely of a 3.3-kb higher-order repeat, with independent copies of this higher-order repeat more than 99% identical to each other… CONTINUE READING
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