Characterization of a stretch-activated potassium channel in chondrocytes

@article{Mobasheri2010CharacterizationOA,
  title={Characterization of a stretch-activated potassium channel in chondrocytes},
  author={A. Mobasheri and R. Lewis and Judith EJ Maxwell and C. Hill and M. Womack and R. Barrett-Jolley},
  journal={Journal of Cellular Physiology},
  year={2010},
  volume={223},
  pages={511 - 518}
}
Chondrocytes possess the capacity to transduce load‐induced mechanical stimuli into electrochemical signals. The aim of this study was to functionally characterize an ion channel activated in response to membrane stretch in isolated primary equine chondrocytes. We used patch‐clamp electrophysiology to functionally characterize this channel and immunohistochemistry to examine its distribution in articular cartilage. In cell‐attached patch experiments, the application of negative pressures to the… Expand
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