Characterization of a single gene cluster responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans.

@article{Ma2012CharacterizationOA,
  title={Characterization of a single gene cluster responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans.},
  author={Junying Ma and Dianguang Zuo and Yongxiang Song and Bo Wang and Hongbo Huang and Yueliang Yao and Wen-Jun Li and Si Hui Zhang and Changsheng Zhang and Jianhua Ju},
  journal={Chembiochem : a European journal of chemical biology},
  year={2012},
  volume={13 4},
  pages={547-52}
}
The nine-membered indolactam antibiotics belong to a small group of antibiotics showing broad biological activities. However, the in vivo genetic engineering of compounds of this type has not been performed. Here we report the identification of a single gene cluster responsible for the biosynthesis of methylpendolmycin and pendolmycin, two members of this… CONTINUE READING