Characterization of a single-chain T-cell receptor expressed in Escherichia coli.

@article{Hoo1992CharacterizationOA,
  title={Characterization of a single-chain T-cell receptor expressed in Escherichia coli.},
  author={W F Hoo and Michael Joseph Lacy and Lisa Kae Denzin and Edward W. Voss and Karl D. Hardman and David Michael Kranz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 10},
  pages={
          4759-63
        }
}
Despite progress in defining the nature of major histocompatibility complex products that are recognized by the T-cell antigen receptor, the binding properties and structure of the receptor have not been solved. The primary problem has been the difficulty in obtaining sufficient quantities of active receptor. In this report we show that a single-chain T-cell receptor gene can be expressed in Escherichia coli. The protein consists of the variable (V) regions of the alpha and beta chains (V alpha… CONTINUE READING
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