Characterization of a serine proteinase mediating encystation of Acanthamoeba.

  title={Characterization of a serine proteinase mediating encystation of Acanthamoeba.},
  author={Eun-Kyung Moon and D G Chung and Yeon-Chul Hong and Hyun-Hee Kong},
  journal={Eukaryotic cell},
  volume={7 9},
Members of the genus Acanthamoeba, amphizoic protozoan parasites, are causative agents of granulomatous amoebic encephalitis and amoebic keratitis. Proteinases play a role in various biologic actions in Acanthamoeba, including host tissue destruction, pathogenesis, and digestion of phagocytosed food. Interestingly, we found that encystation of Acanthamoeba was inhibited by the serine proteinase inhibitor phenylmethanesulfonyl fluoride. In this study, we characterize a serine proteinase that is… CONTINUE READING
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