Characterization of a quadruple glycoprotein-deleted pseudorabies virus mutant for use as a biologically safe live virus vaccine.

@article{Mettenleiter1994CharacterizationOA,
  title={Characterization of a quadruple glycoprotein-deleted pseudorabies virus mutant for use as a biologically safe live virus vaccine.},
  author={Thomas C Mettenleiter and Barbara G. Klupp and Frank Weiland and Nico Visser},
  journal={The Journal of general virology},
  year={1994},
  volume={75 ( Pt 7)},
  pages={1723-33}
}
Herpesvirus envelope glycoproteins play important roles in mediating infection initiation and also represent major immunogens. We recently showed that a pseudorabies virus (PrV) mutant lacking the essential glycoprotein gD (gp50), after phenotypic complementation by propagation on genetically engineered PrV gD-expressing cell lines was able to infect primary target cells and spread exclusively by means of direct cell-to-cell transmission. Virions released from non-complementing cells that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Pathogenic Pseudorabies Virus, China, 2012

Emerging infectious diseases • 2014

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Characterization of the envelope proteins of pseudorabies virus

A S.
Journal of Virology • 1984
View 3 Excerpts
Highly Influenced

Entry of alphaherpesviruses into cells

P G.
Seminars in Virology • 1993

a). Deleting valine- 125 and cysteine- 126 in glycoprotein gI of pseudorabies virus strain NIA-3 decreases plaque size and reduces virulence in mice

J. VAN OIRSCHOT
Virology • 1993

Similar Papers

Loading similar papers…