Characterization of a potential animal model of an idiosyncratic drug reaction: Nevirapine-induced skin rash in the rat

@article{Shenton2003CharacterizationOA,
  title={Characterization of a potential animal model of an idiosyncratic drug reaction: Nevirapine-induced skin rash in the rat},
  author={Jacintha M. Shenton and Munehiro Teranishi and Mones Abu-Asab and Julie A. Yager and Jack Uetrecht},
  journal={Chemical Research in Toxicology},
  year={2003},
  volume={16},
  pages={1078-1089}
}
Idiosyncratic drug reactions are difficult to study in humans due to their unpredictability. Unfortunately, this characteristic also hinders the development of animal models needed for mechanistic studies. Nevirapine, used to treat human immunodeficiency virus (HIV) infections, results in a severe idiosyncratic skin rash in some patients. We found that nevirapine can also cause a significant rash in some strains of rats. At a dose of 150 mg/kg/day, the incidence in female Sprague-Dawley rats… CONTINUE READING

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