Characterization of a pore-forming cytotoxin expressed by Salmonella enterica serovars typhi and paratyphi A.

@article{Oscarsson2002CharacterizationOA,
  title={Characterization of a pore-forming cytotoxin expressed by Salmonella enterica serovars typhi and paratyphi A.},
  author={Jan Oscarsson and Marie Westermark and Sven L{\"o}fdahl and B. Bornefeldt Olsen and Helena Palmgren and Yoshimitsu Mizunoe and Sun Nyunt Wai and Bernt Eric Uhlin},
  journal={Infection and immunity},
  year={2002},
  volume={70 10},
  pages={5759-69}
}
Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene that has been characterized so far only in Escherichia coli. Using DNA sequence analysis and PCR, we established that clyA is conserved in the human-specific typhoid Salmonella enterica serovars Typhi and Paratyphi A and that the entire clyA gene locus is absent in many other S. enterica serovars, including Typhimurium. The gene products, designated ClyA(STy) and ClyA(SPa), show >/=90% amino acid identity to E. coli… CONTINUE READING
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