Characterization of a phosphatase specific for 2‐deoxyglucose‐6‐phosphate in a yeast mutant

@article{Martin1977CharacterizationOA,
  title={Characterization of a phosphatase specific for 2‐deoxyglucose‐6‐phosphate in a yeast mutant},
  author={M. Martín and Claudio F. Heredia},
  journal={FEBS Letters},
  year={1977},
  volume={83}
}
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24 Citations
Background Citations
10
Methods Citations
1

24 Citations

Citation Type

Citation Type

The expression of a specific 2-deoxyglucose-6P phosphatase prevents catabolite repression mediated by 2-deoxyglucose in yeast
TLDR
It was found that in DOGR yeasts, 2-DOG was not able to trigger glucose repression, even at concentrations of 0.5%.
Molecular characterization of a gene that confers 2‐deoxyglucose resistance in yeast
TLDR
A gene whose expression enables yeast cells to overcome the inhibition of growth produced by the presence of 2‐deoxyglucose is isolated, which contains an open reading frame that may code for a protein of 27 100 Da.
Derepressed 2-deoxyglucose-resistant mutants of Aspergillus niger with altered hexokinase and acid phosphatase activity in hyperproduction of β-fructofuranosidase
TLDR
Aspergillus niger NRRL330 produces extracellular β-fructofuranosidase (Ffase), and its production is subject to repression by hexoses in the medium, suggesting that phosphorylation and dephosphorylation steps could attribute to the 2-DG resistance of A. niger.
EFFECTS OF HEXOSE ANALOGUES ON FUNGI: MECHANISMS OF INGIBITION AND OF RESISTANCE
TLDR
There are indications that sorbose, perhaps by interfering with cell wall structure, affects hyphal morphogenesis and that this effect may be magnified into a macroscopic change in the characteristics of the colony during growth on solid medium by secondary environmental effects.
Purification and Characterization of Two Isoenzymes of DL-Glycerol-3-phosphatase from Saccharomyces cerevisiae
TLDR
Together with DOG1 and DOG2, encoding two highly homologous enzymes that dephosphorylate 2-deoxyglucose-6-phosphate, GPP1 and GPP2 constitute a new family of genes for low molecular weight phosphatases.
Deoxyglucose-resistant mutants of Neurospora crassa: isolation, mapping, and biochemical characterization
TLDR
Neurospora crassa mutants resistant to 2-deoxyglucose have been isolated, and their mutations have been mapped to four genetic loci, suggesting altered posttranslational modification.
Enhancement of xylose uptake in 2-deoxyglucose tolerant mutant of Saccharomyces cerevisiae.
A Kluyveromyces marxianus 2-deoxyglucose-resistant mutant with enhanced activity of xylose utilization.
TLDR
One isolate had a single nucleotide mutation to cause amino acid substitution (G270S) in RAG5 encoding hexokinase and exhibited very low activity of the enzyme, suggesting the possible mechanism of defectiveness of glucose repression in the mutant is discussed.
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose
TLDR
Results show that HAD-like phosphatases are evolutionarily conserved regulators of 2DG resistance and suggest that cancer cells with increased abundance of this phosphatase could escape the toxic effects of2DG.
Citric acid production by 2-deoxyglucose-resistant mutant strains of Aspergillus niger
SummaryMany mutant strains showing resistance to 2-deoxy-d-glucose (DG) on minimal medium containing glycerol as a carbon source were induced from Aspergillus niger WU-2223L, a citric acid-producing…
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